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Primum Non Nocere

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NEURAL CONTROL OF THE HEART

Sympathetic stimulation(β1)  speeds up the sinus node (sinus tachycardia) and vagal activity (M2) slows the node (sinus bradycardia).

Increased concentration of the sympathetic transmitter noradrenaline, and of adrenaline from the adrenal glands, cause positive inotropic state (increased contractility), positive chronotropic state (increased frequency), positive dromotropic state (increased conduction velocity), and positive bathmotropic state (increased irritability) on the heart.

Noradrenaline activates a-adrenergic constrictor receptors in the coronary vessels, whereas adrenaline activates b-adrenergic vasodilatator receptors.

The neurotransmitter acetylcholine, activating muscarinic receptors, and vagal stimulation causes negative inotropynegative chronotropy, negative dromotropy, and negative bathmotropy.

(Source: zuniv.net)

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